The feat caps off a remarkable start to the year for the 23-year-old, who was one of England's most impressive players at the Six Nations.
Elsewhere, Irish make five changes to the side that lost at Exeter Chiefs in their last outing, with Delon Armitage, Sailosi Tagicakibau and Tom Homer making up the back three.
Joe Ansbro moves from outside centre to inside centre and is joined by Jonathan Joseph while Matt Garvey moves from the back row to the second row to partner Bryn Evans.
Exiles head coach Toby Booth said: "It is great to be back playing in front of our home supporters at Madejski Stadium. We have enjoyed a successful week's training in the lead up to this match and are ready for what is sure to be a tough encounter."
Irish team: 15. Tom Homer; 14. Delon Armitage; 13. Jonathan Joseph; 12. Joe Ansbro; 11. Sailosi Tagicakibau; 10. Adrian Jarvis; 9. Darren Allinson; 1.Alex Corbisiero (Captain); 2. David Paice; 3. Faan Rautenbach; 4. Bryn Evans; 5. Matt Garvey; 6. Jamie Gibson; 7. Richard Thorpe; 8. Ofisa Treviranus.
Replacements: 16. James Buckland; 17. Max Lahiff; 18. Leo Halavatau; 19. Jebb Sinclair; 20. Alex Gray; 21. Topsy Ojo; 22. Steve Shingler; 23. Ross Samson.